Buzi F, Zanotti P, Tiberti A, Monteleone M, Lombardi A, Ugazio A G
Department of Pediatrics, University of Brescia, Italy.
J Clin Endocrinol Metab. 1993 Dec;77(6):1495-9. doi: 10.1210/jcem.77.6.8263132.
to analyze the interrelationships between GH secretion and pattern of sleep.
18 children (10 male, 8 female; mean age 9.1 yr, range 5.1-14.3 yr), with short stature (mean height standard deviation score (SDS) -2.52, range -3.86-(-)1.88; mean height velocity SDS -1.1, range -2.40-(-)0.08), including 9 children with genetic short stature and 9 with idiopathic short stature.
blood samples were taken every 15 min from 2000 h-0800 h, and GH profiles were analyzed by the PULSAR computerized peak identification algorithm; simultaneous sleep was analyzed by electroencephalogram recording.
no significant correlation was noted between GH secretion parameters and any of the electroencephalogram parameters evaluated: stage 1 (S1) percent, stage 2 (S2) percent, slow-wave sleep (SWS) percent, rapid eye movement sleep percent, wakefulness (W) percent, and sleep efficiency (EFF); there was no significant difference in GH secretion between children with EFF less than 76% and those with EFF more than 76% (P > 0.5). Maximal GH peak coincided 9 times (50%) with SWS, 3 times (17%) with S2, 3 times with W, twice (11%) with S1, and once (6%) with rapid eye movement sleep. First GH peak coincided 12 times (67%) with W, 3 times with S2, twice with SWS, and once with S1. There was no significant difference comparing the percentage of sleep stages occurring in the 15 min of maximal GH increment, in the 15 min preceding it, and in those following it; there was no significant difference comparing the percentage of sleep stages occurring in the 15 min preceding the onset of a GH peak and in those following it.
GH secretion in short children seems independent of the sleep stage and efficiency; in children it is possible that GH secretion relates with sleep per se and with neurohormonal changes occurring at nighttime rather than with a specific sleep stage or sleep stage sequence.
分析生长激素（GH）分泌与睡眠模式之间的相互关系。
18名儿童（男10名，女8名；平均年龄9.1岁，范围5.1 - 14.3岁），身材矮小（平均身高标准差评分（SDS）-2.52，范围-3.86 - (-)1.88；平均身高增长速度SDS -1.1，范围-2.40 - (-)0.08），其中包括9名遗传性身材矮小儿童和9名特发性身材矮小儿童。
从20:00至08:00每15分钟采集一次血样，采用PULSAR计算机化峰值识别算法分析GH谱；同时通过脑电图记录分析睡眠情况。
未发现GH分泌参数与所评估的任何脑电图参数之间存在显著相关性：第1阶段（S1）百分比、第2阶段（S2）百分比、慢波睡眠（SWS）百分比、快速眼动睡眠百分比、清醒（W）百分比和睡眠效率（EFF）；EFF低于76%的儿童与EFF高于76%的儿童之间的GH分泌无显著差异（P > 0.5）。最大GH峰值与SWS同时出现9次（50%），与S2同时出现3次（17%），与W同时出现3次，与S1同时出现2次（11%），与快速眼动睡眠同时出现1次（6%）。第一个GH峰值与W同时出现12次（67%），与S2同时出现3次，与SWS同时出现2次，与S1同时出现1次。比较最大GH增量的15分钟内、其前15分钟和其后15分钟出现的睡眠阶段百分比，无显著差异；比较GH峰值出现前15分钟和其后15分钟出现的睡眠阶段百分比，也无显著差异。
身材矮小儿童的GH分泌似乎与睡眠阶段和效率无关；在儿童中，GH分泌可能与睡眠本身以及夜间发生的神经激素变化有关，而不是与特定的睡眠阶段或睡眠阶段顺序有关。
