Rand J S, Levine J, Best S J, Parker W
School of Veterinary Science, University of Queensland, Australia.
J Vet Intern Med. 1993 Sep-Oct;7(5):272-6. doi: 10.1111/j.1939-1676.1993.tb01019.x.
Spontaneous adult-onset hypothyroidism, confirmed by a thyroid-stimulating hormone stimulation test, thyroid biopsy, and response to replacement therapy, is described in a female cat. Clinical signs consisted of profound apathy, hypothermia, poor hair growth, severe seborrhea sicca, and a puffy face. Cutaneous histological changes consisted of epidermal and follicular hyperkeratosis, teloginization of hairs, and dermal mucin deposition. There was no adnexal atrophy. Lymphocytic thyroiditis, equivalent to Hashimoto's thyroiditis, was shown by thyroid biopsy. Clinical signs rapidly responded to thyroxine replacement therapy. Glucose intolerance was coexistent with the hypothyroidism, but was not dramatically influenced by thyroxine therapy and probably was an independently occurring endocrinopathy.
一只雌性猫被诊断为自发性成年期甲状腺功能减退，该诊断通过促甲状腺激素刺激试验、甲状腺活检以及对替代疗法的反应得以证实。临床症状包括极度冷漠、体温过低、毛发生长不良、严重干性皮脂溢以及脸部浮肿。皮肤组织学变化包括表皮和毛囊角化过度、毛发休止期延长以及真皮粘蛋白沉积。未见附属器萎缩。甲状腺活检显示为淋巴细胞性甲状腺炎，等同于桥本甲状腺炎。临床症状对甲状腺素替代疗法反应迅速。葡萄糖不耐受与甲状腺功能减退并存，但甲状腺素治疗对其影响不大，可能是一种独立发生的内分泌病。
