Lockard J S, Levy R H
Epilepsia. 1976 Dec;17(4):477-9. doi: 10.1111/j.1528-1157.1976.tb04459.x.
Valproic acid [dipropylacetic acid (DPA)] was evaluated in an alumina-gel monkey model (N = 12) by constant-rate intravenous infusion. The data indicated: (a) a statistically significant decrease in seizure frequency the first 2 days of drug Step I (45-55 mug/ml) and drug Step II (90-110 mug/ml) which was temporary, lasting 2 days only; (b) a later, more permanent decrease in siezure frequency which was not apparent until drug Setp III (130-170 mug/ml); and a delayed return of the seizure frequency to predrug levels for 2 weeks after drug administration was discontinued, with no DPA detectable in plasma after the initial postdrug day. Whether DPA will behave as a reversibly acting drug was discussed.
通过恒速静脉输注，在氧化铝凝胶猴模型（N = 12）中评估了丙戊酸[二丙基乙酸（DPA）]。数据表明：（a）在药物步骤I（45 - 55微克/毫升）和药物步骤II（90 - 110微克/毫升）的头2天，癫痫发作频率有统计学意义的显著下降，但这是暂时的，仅持续2天；（b）后来癫痫发作频率有更持久的下降，直到药物步骤III（130 - 170微克/毫升）才明显；并且在停药后癫痫发作频率延迟2周恢复到给药前水平，给药后最初几天过后血浆中未检测到DPA。讨论了DPA是否会表现为一种可逆作用的药物。
