在相关兔中产生的单克隆抗体的活性异源链重组体。
Active heterologous chain recombinants of monoclonal antibodies raised in related rabbits.
作者信息
Braun D G, Riesen W F, Huser H
出版信息
Eur J Immunol. 1976 Nov;6(11):819-22. doi: 10.1002/eji.1830061113.
PMID:826398
Abstract
Heterologous chain recombinants of homogeneous anti-streptococcal group A-variant polysaccharide antibodies produced by pedigreed rabbits regain in certain pairs the same antigen-binding capacity as the homologous pairs. In contrast, chain recombinants with antibodies from nonrelated rabbits are much less active. This data suggests random pairing of immunoglobulin heavy and light chains coded for in the germ line and subsequent selection.
摘要
纯种兔产生的抗A组链球菌变异多糖抗体的同源链重组体，在某些配对中恢复了与同源配对相同的抗原结合能力。相比之下，来自非亲缘关系兔子的抗体的链重组体活性要低得多。该数据表明，种系中编码的免疫球蛋白重链和轻链随机配对并随后进行选择。
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