Langan E M, Youkey J R, Franklin D P, Elmore J R, Costello J M, Nassef L A
Section of Vascular Surgery, Geisinger Clinic, Danville, PA 17822.
J Vasc Surg. 1993 Dec;18(6):905-11; discussion 912-3.
This study evaluates dobutamine stress echocardiography (DSE) for perioperative cardiac risk assessment with elective aortic surgery.
Dobutamine stress echocardiography was used to evaluate 81 patients before infrarenal aortic surgery. Patients were placed into three groups. Group I (n = 31) had normal DSEs. Group II (n = 25) had resting wall motion abnormalities without dobutamine-induced changes of ischemia. Group III (n = 25) had evidence of dobutamine-induced ischemia. Patient analysis revealed that of 46 patients with clinical indicators of coronary artery disease (CAD), only 23 had DSEs with inducible ischemia. Two of 35 patients without clinical indicators of CAD had DSEs with inducible ischemia.
The 56 patients in group I and II underwent aortic reconstruction without cardiac complications or death. Of the 25 patients in group III, surgery was deferred in five (two patients with claudication and three with aneurysms < or = 5 cm), and four underwent coronary artery bypass grafting. Outcome after coronary artery bypass grafting included one death from stroke, one aneurysm rupture, and two uncomplicated aortic reconstructions. The remaining 16 patients in group III underwent aortic surgery, with three postoperative myocardial infarctions (MI) and no deaths.
Using DSE for preoperative assessment of cardiac risk allowed us to operate on 74 of 81 patients being considered for elective aortic reconstruction, with no operative deaths and a 4.1% rate of perioperative MI. Dobutamine stress echocardiography has the ability to identify patients with asymptomatic stress-induced ischemic myocardium and its increased risk for perioperative MI (p < 0.001). Equally important, for patients with clinical indicators of CAD but without DSE-inducible ischemia, no further cardiac evaluation is necessary.
本研究评估多巴酚丁胺负荷超声心动图(DSE)在择期主动脉手术围手术期心脏风险评估中的应用。
采用多巴酚丁胺负荷超声心动图对81例肾下腹主动脉手术患者进行术前评估。患者被分为三组。第一组(n = 31)DSE结果正常。第二组(n = 25)静息时存在室壁运动异常,但多巴酚丁胺激发试验未诱发缺血改变。第三组(n = 25)有多巴酚丁胺诱发缺血的证据。患者分析显示,46例有冠状动脉疾病(CAD)临床指标的患者中,只有23例DSE显示有诱发性缺血。35例无CAD临床指标的患者中有2例DSE显示有诱发性缺血。
第一组和第二组的56例患者接受了主动脉重建,无心脏并发症或死亡。第三组的25例患者中,5例(2例间歇性跛行患者和3例动脉瘤直径≤5 cm的患者)手术延期,4例接受了冠状动脉旁路移植术。冠状动脉旁路移植术后的结果包括1例因中风死亡、1例动脉瘤破裂和2例主动脉重建未出现并发症。第三组其余16例患者接受了主动脉手术,术后发生3例心肌梗死(MI),无死亡病例。
使用DSE进行术前心脏风险评估,使我们能够对81例考虑择期主动脉重建的患者中的74例进行手术,无手术死亡,围手术期MI发生率为4.1%。多巴酚丁胺负荷超声心动图能够识别无症状性应激诱发的缺血性心肌患者及其围手术期MI风险增加(p < 0.001)。同样重要的是,对于有CAD临床指标但无DSE诱发性缺血的患者,无需进一步进行心脏评估。