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大鼠耳蜗核中星形胶质细胞的细胞构筑:一项免疫细胞化学研究。

Astrocyte cytoarchitecture in cochlear nuclei of the rat: an immunocytochemical study.

作者信息

Valderrama-Canales F J, Gil-Loyzaga P, Merchan-Perez A, Sanchez J G

机构信息

Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad Complutense, Madrid, España.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1993 Nov-Dec;55(6):313-6. doi: 10.1159/000276446.

DOI:10.1159/000276446
PMID:8265113
Abstract

Astrocytes play important roles in the development, maintenance and function of neural circuits. We have studied the astrocytic cytoarchitecture of the adult rat cochlear nuclei using a monoclonal antibody against glial fibrillary acidic protein, a well-known intermediate filament of the cytoskeleton of the glial cells. The cochlear nuclear complex is the first central step in the ascending auditory pathway. The morphology and distribution of astrocytes, as well as the relationship of astroglial processes with neurons, have been found to be different in the three main subdivisions of the cochlear nuclei and could be related to their function.

摘要

星形胶质细胞在神经回路的发育、维持和功能中发挥着重要作用。我们使用针对胶质纤维酸性蛋白(一种众所周知的神经胶质细胞细胞骨架中间丝)的单克隆抗体,研究了成年大鼠耳蜗核的星形胶质细胞细胞结构。耳蜗核复合体是听觉上行通路的第一个中枢步骤。已发现星形胶质细胞的形态和分布,以及星形胶质细胞突起与神经元的关系,在耳蜗核的三个主要亚区有所不同,并且可能与其功能有关。

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