Vermeesch J R, Williams D, Price C M
Department of Chemistry, University of Nebraska-Lincoln 68588-0304.
Nucleic Acids Res. 1993 Nov 25;21(23):5366-71. doi: 10.1093/nar/21.23.5366.
In Euplotes crassus millions of telomeres are synthesized during the sexual phase of the life cycle. Since these newly synthesized telomeres are longer than normal macronuclear telomeres, they must be trimmed to the mature size. We have examined the timing and mechanism of this trimming step. We have shown that a sudden decrease in telomere length takes place at a specific time during macronuclear development. The decrease in telomere length is not caused by incomplete replication of the most terminal DNA sequences; rather it is the result of an active processing event that occurs independently of DNA replication. The developmentally regulated telomere shortening that takes place in Euplotes is reminiscent of the sudden reductions in telomere length which have been observed in other eukaryotes.
在粗壮游仆虫（Euplotes crassus）的生命周期有性阶段，数百万个端粒被合成。由于这些新合成的端粒比正常的大核端粒长，它们必须被修剪至成熟大小。我们研究了这一修剪步骤的时间和机制。我们已经表明，在大核发育的特定时间，端粒长度会突然缩短。端粒长度的缩短并非由最末端DNA序列的不完全复制引起；相反，它是一个独立于DNA复制发生的主动加工事件的结果。在游仆虫中发生的发育调控端粒缩短让人联想到在其他真核生物中观察到的端粒长度的突然减少。
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