Andolina M, Giorgi R, Maximova N, Comar M
Clinica Pediatrica, Istituto per l'Infanzia Burlo Garofolo di Trieste.
Pediatr Med Chir. 1993 Jul-Aug;15(4):347-8.
Intravenous immunoglobulins have a role also in the prevention of infections after a bone marrow transplantation. Even if a reduction of CMV pneumonia is reported it is not clear whether such an effect is due to a direct antiviral activity or it is mediated through an immune modulation that reduces GVHD and then the immune suppression. We are currently using i.v.Ig at a dose of 100 mg/kg/day within a protocol for GVHD prophylaxis after a mismatched BMT.
静脉注射免疫球蛋白在预防骨髓移植后感染方面也有作用。即使有报道称巨细胞病毒肺炎有所减少，但尚不清楚这种效果是由于直接的抗病毒活性，还是通过减少移植物抗宿主病进而减少免疫抑制的免疫调节作用介导的。我们目前正在一项不匹配骨髓移植后预防移植物抗宿主病的方案中，以100毫克/千克/天的剂量使用静脉注射免疫球蛋白。
