Williams D M, Sawyer S, Remington J S
J Infect Dis. 1976 Dec;134(6):610-23. doi: 10.1093/infdis/134.6.610.
The role of the activated macrophage in resistance of mice to infection with Trypanosoma cruzi was investigated with use of mice that had not been infected with T. cruzi but whose macrophages were activated by Toxoplasma gondii or Besnoitia jellisoni. Mice with activated macrophages were significantly more resistant to intra-peritoneal challenge with the Tulahuen strain of T. cruzi than were controls. The role of serum factors in resistance to T. cruzi was excluded by the demonstration of no difference between survival of T. cruzi in serum from mice with activated macrophages and in that from controls. As the only modality of resistance to T. cruzi in this in vivo model appeared to be the activated macrophage, this cell was investigated in vitro. Activated macrophages were shown to be able to inhibit completely multiplication of T. cruzi, whereas significant multiplication of the parasite occurred in control macrophages. Both in vivo and in vitro data suggest that the activated macrophage may play a major role in resistance to infection with T. cruzi.
利用未感染克氏锥虫但巨噬细胞被刚地弓形虫或杰氏贝诺孢子虫激活的小鼠，研究了活化巨噬细胞在小鼠抵抗克氏锥虫感染中的作用。与对照相比，巨噬细胞活化的小鼠对克氏锥虫图拉韦恩株腹腔攻击的抵抗力显著更强。通过证明活化巨噬细胞小鼠血清与对照小鼠血清中克氏锥虫的存活情况无差异，排除了血清因子在抵抗克氏锥虫中的作用。由于在这个体内模型中，抵抗克氏锥虫的唯一方式似乎是活化巨噬细胞，因此对这种细胞进行了体外研究。结果表明，活化巨噬细胞能够完全抑制克氏锥虫的增殖，而在对照巨噬细胞中，该寄生虫则大量增殖。体内和体外数据均表明，活化巨噬细胞可能在抵抗克氏锥虫感染中起主要作用。
