小鼠巨噬细胞在体外的杀念珠菌活性。
Candidacidal activity of mouse macrophages in vitro.
作者信息
Maiti P K, Kumar R, Mohapatra L N
出版信息
Infect Immun. 1980 Aug;29(2):477-82. doi: 10.1128/iai.29.2.477-482.1980.
Abstract
Mouse peritoneal macrophages were infected in vitro with Candida albicans, and the phagocytic and candidacidal activities were estimated by microscopic examination of Giemsa-stained cells. Activated macrophages obtained from either BCG-vaccinated animals or by in vitro exposure of normal macrophages to phytohemagglutinin-induced lymphokines exhibited higher phagocytic and candidacidal activities than did normal macrophages. However, activated macrophages obtained by in vitro exposure of macrophages to candida-induced lymphokines exhibited the highest phagocytic and candidacidal activities. The incorporation of immune mouse serum into the culture medium also enhanced the phagocytic and candidacidal activities of the normal macrophages but failed to improve the function of the activated macrophages. These results suggest that both activated macrophages and antibodies may be required for controlling candida infections in mice.
摘要
用白色念珠菌在体外感染小鼠腹腔巨噬细胞，并通过对吉姆萨染色细胞进行显微镜检查来评估吞噬和杀念珠菌活性。从接种卡介苗的动物获得的活化巨噬细胞，或通过在体外将正常巨噬细胞暴露于植物血凝素诱导的淋巴因子而获得的活化巨噬细胞，其吞噬和杀念珠菌活性均高于正常巨噬细胞。然而，通过在体外将巨噬细胞暴露于念珠菌诱导的淋巴因子而获得的活化巨噬细胞表现出最高的吞噬和杀念珠菌活性。将免疫小鼠血清加入培养基中也增强了正常巨噬细胞的吞噬和杀念珠菌活性，但未能改善活化巨噬细胞的功能。这些结果表明，活化巨噬细胞和抗体可能都是控制小鼠念珠菌感染所必需的。
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