Chan C N, Tan A T, Koh T H, Chee T S, Ding Z P
Department of Cardiology, Singapore General Hospital.
Singapore Med J. 1993 Apr;34(2):115-7.
Between June 1990 and August 1991, 28 percutaneous transseptal balloon mitral valvotomy procedures were attempted in 27 patients (23 women and 4 men; mean age 39.8 +/- 9.3 years) with severe mitral stenosis. Successful mitral valvotomy was achieved in 25 patients (primary success rate of 92%). Mitral valve area increased from 0.82 +/- 0.17 cm2 to 1.53 +/- 0.48 cm2 (p < 0.001) and the mean mitral valve gradient decreased from 13.4 +/- 7.4 to 6.0 +/- 5.4 mmHg (p < 0.05). There were no deaths, one patient had cardiac tamponade after transseptal puncture and required emergency pericardiocentesis with successful percutaneous balloon valvotomy 6 months later. One patient had an unsuccessful valvotomy because the mitral valve could not be crossed and another patient had an inadequate dilatation. Our initial experience in percutaneous transseptal mitral valvotomy confirms the safety and efficacy of this new technique for the treatment of rheumatic mitral stenosis.
1990年6月至1991年8月期间，对27例（23例女性和4例男性；平均年龄39.8±9.3岁）重度二尖瓣狭窄患者尝试进行了28次经皮经间隔球囊二尖瓣成形术。25例患者二尖瓣成形术成功（初步成功率为92%）。二尖瓣面积从0.82±0.17 cm²增加至1.53±0.48 cm²（p<0.001），二尖瓣平均压差从13.4±7.4降至6.0±5.4 mmHg（p<0.05）。无死亡病例，1例患者经间隔穿刺后发生心脏压塞，需紧急心包穿刺，6个月后成功进行经皮球囊瓣膜成形术。1例患者瓣膜成形术未成功，原因是二尖瓣无法通过，另1例患者扩张不充分。我们经皮经间隔二尖瓣成形术的初步经验证实了这项治疗风湿性二尖瓣狭窄新技术的安全性和有效性。
