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外用苯妥英作为固定疗法辅助手段治疗营养性麻风溃疡。

The use of topical phenytoin as an adjunct to immobilization in the treatment of trophic leprosy ulcers.

作者信息

Menezes J, Rajendran A, Jacob A J, Vaz M

机构信息

Emmaus-Swiss Leprosy Project, Andhra Pradesh, India.

出版信息

Southeast Asian J Trop Med Public Health. 1993 Jun;24(2):340-2.

PMID:8266239
Abstract

A total of 30 leprosy patients (controls n = 16; topical phenytoin n = 14) with trophic ulcers on the feet were investigated to ascertain the efficacy of topical phenytoin powder in the healing of ulcers. The ulcers in the two groups were matched for initial size. Healing patterns were assessed by determining changes in depth and planar (surface) dimensions at weekly intervals over a three week study period. Results indicate that while immobilization of the ulcer site is effective in promoting ulcer healing, additional use of topical phenytoin accelerates the healing process. There may however be non-responders to topical phenytoin.

摘要

共对30例足部有营养性溃疡的麻风患者(对照组n = 16;局部使用苯妥英组n = 14)进行了研究,以确定局部使用苯妥英粉对溃疡愈合的疗效。两组溃疡的初始大小相匹配。在为期三周的研究期间,通过每周测定深度和平面(表面)尺寸的变化来评估愈合模式。结果表明,虽然溃疡部位固定对促进溃疡愈合有效,但额外使用局部苯妥英可加速愈合过程。然而,可能存在对局部苯妥英无反应者。

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