加蓬基于人群的血清乙型肝炎病毒DNA研究。

Population-based study of serum hepatitis B virus DNA in Gabon.

作者信息

Dazza M C, Trebucq A, Gaudebout C, Jarretou A, Le Hesran J Y, Josse R, Delaporte E, Bréchot C, Larouze B

机构信息

INSERM U13, Hôpital Claude Bernard, Paris, France.

出版信息

Trans R Soc Trop Med Hyg. 1993 Sep-Oct;87(5):539-40. doi: 10.1016/0035-9203(93)90078-5.

DOI:10.1016/0035-9203(93)90078-5

PMID:8266404

Abstract

The prevalence of serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) was measured in a Gabonese community at high risk for HBV infection. Among 698 subjects 5 to 24 years old, the prevalence of HBsAg was 11.1% vs. 57.9% for anti-HBs and 7.2% for anti-HBc alone. The prevalence of HBeAg among HBsAg-positive subjects was 26.5% vs. 59.5% for anti-HBe. The prevalence of HBV DNA tested by a hybridization spot test was 2.1% in the overall population and 18.7% among HBsAg-positive subjects. HBV DNA was found in 15 of 21 HBeAg-positive subjects but in none of the subjects positive for anti-HBe or negative for both HBeAg and anti-HBe. HBV DNA was not detected in any HBsAg negative subjects. The prevalence of HBV DNA decreased with age. This low prevalence of HBV DNA contrasts with the high level of endemicity in the study population.

摘要

在一个乙肝病毒（HBV）感染高危的加蓬社区，对血清HBV脱氧核糖核酸（DNA）的流行情况进行了测定。在698名5至24岁的受试者中，HBsAg的流行率为11.1%，抗-HBs为57.9%，单独抗-HBc为7.2%。在HBsAg阳性受试者中，HBeAg的流行率为26.5%，抗-HBe为59.5%。通过杂交斑点试验检测的HBV DNA在总体人群中的流行率为2.1%，在HBsAg阳性受试者中为18.7%。在21名HBeAg阳性受试者中有15名检测到HBV DNA，但在抗-HBe阳性或HBeAg和抗-HBe均为阴性的受试者中未检测到。在任何HBsAg阴性受试者中均未检测到HBV DNA。HBV DNA的流行率随年龄下降。这种HBV DNA的低流行率与研究人群中的高流行程度形成对比。