Schmidt J D, Jacobo E C, Weinstein S H
J Urol. 1976 Dec;116(6):734-6. doi: 10.1016/s0022-5347(17)58990-9.
In an evaluation of the use of topical triethylenethiophosphoramide for therapy and prevention of recurrent multiple superficial transitional cell carcinoma of the bladder retrograde cystography was done. Unilateral or bilateral vesicoureteral reflux was demonstrated in 9 consecutive patients studied. Retrospective analysis uncovered 9 additional patients with bladder cancer and reflux. The discovery of vesicoureteral reflux prompts currently unanswerable questions regarding the etiology and pathogenesis of urothelial malignancy, as well as the role of topical chemotherapy in superficial tumors.
在一项关于使用局部三乙烯硫代磷酰胺治疗和预防复发性多发性浅表性膀胱移行细胞癌的评估中，进行了逆行膀胱造影。在连续研究的9例患者中显示出单侧或双侧膀胱输尿管反流。回顾性分析又发现了9例患有膀胱癌和反流的患者。膀胱输尿管反流的发现引发了目前关于尿路上皮恶性肿瘤的病因和发病机制以及局部化疗在浅表肿瘤中的作用等无法回答的问题。
