Tucker J A
Department of Pathology, University of South Alabama, Mobile.
Ultrastruct Pathol. 1993 May-Aug;17(3-4):279-86. doi: 10.3109/01913129309027774.
Classically, ultrastructural examination of alveolar soft part sarcoma reveals large, dramatic, rhomboid to needlelike crystals with a characteristic substructure. In this study of four cases of alveolar soft part sarcoma, only two exhibited large crystals, which were rare. All four cases, however, exhibited round, electron-dense granules, and in the two cases without large crystals these granules rarely exhibited elongation with the characteristic substructure of alveolar soft part sarcoma that permits definitive diagnosis. Two of these cases had been previously studied at other institutions, where crystals were not identified ultrastructurally and electron microscopy was considered noncontributory. Large crystals, then, may be rare or absent in alveolar soft part sarcoma. Careful search may be necessary to find granules with the characteristic periodic substructure.
传统上，肺泡软组织肉瘤的超微结构检查显示有大的、显著的、菱形至针状的晶体，具有特征性的亚结构。在这项对4例肺泡软组织肉瘤的研究中，只有2例显示有大晶体，且较为罕见。然而，所有4例均显示有圆形的电子致密颗粒，在没有大晶体的2例中，这些颗粒很少呈现出具有肺泡软组织肉瘤特征性亚结构的伸长，而这种特征性亚结构有助于明确诊断。其中2例之前在其他机构进行过研究，在那里超微结构未发现晶体，且电子显微镜检查被认为没有帮助。因此，大晶体在肺泡软组织肉瘤中可能很少见或不存在。可能需要仔细寻找具有特征性周期性亚结构的颗粒。
