Carlson J A, Dickersin G R
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Ultrastruct Pathol. 1993 May-Aug;17(3-4):353-72. doi: 10.3109/01913129309027780.
An unusual case of peripheral melanotic paraganglioid carcinoid tumor of the lung is described. By light microscopic, immunohistochemical, and electron microscopic examination, melanocytic, schwannian, and neuroepithelial lines of differentiation were evident. This case may represent another example of neoplastic multidirectional differentiation and highlights the close relationship among the genes represented in these three cell lines. In addition, these findings support the concept of a neoplastic origin for the sustentacular cells found in some bronchial carcinoid tumors.
本文描述了一例罕见的肺外周黑色素性副神经节样类癌肿瘤。通过光镜、免疫组化和电镜检查，黑色素细胞、雪旺细胞和神经上皮分化谱系明显。该病例可能代表肿瘤多向分化的另一个例子，并突出了这三种细胞系中所代表基因之间的密切关系。此外，这些发现支持了一些支气管类癌肿瘤中支持细胞肿瘤起源的概念。
