Stability of fluconazole in an extemporaneously prepared oral liquid.

The stability of fluconazole in an extemporaneously prepared oral liquid was studied. An aqueous liquid formulation of fluconazole was prepared by reconstituting the powder from triturated 100-mg tablets with deionized water; the nominal fluconazole concentration was 1 mg/mL. Glass vials of the liquid were stored in the dark at 4, 23, and 45 degrees C and sampled immediately and after 1, 2, 3, and 15 days. Samples were analyzed in duplicate for fluconazole concentration by high-performance liquid chromatography. The concentration of fluconazole was virtually unchanged under all the storage conditions. The results were confirmed by analysis of variance. Fluconazole 1 mg/mL in an extemporaneously prepared oral liquid was stable at 4, 23, and 45 degrees C for up to 15 days.