新型基于潜在机制的人白细胞弹性蛋白酶和组织蛋白酶G抑制剂：异噻唑烷-3-酮衍生物
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one.
作者信息
Groutas W C, Chong L S, Venkataraman R
机构信息
Department of Chemistry, Wichita State University, KS 67260.
出版信息
Biochem Biophys Res Commun. 1993 Dec 15;197(2):730-9. doi: 10.1006/bbrc.1993.2540.
PMID:8267609
Abstract
A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to be effective inhibitors of cathepsin G.
摘要
已合成了一系列设计用作人白细胞弹性蛋白酶和组织蛋白酶G的基于机制的抑制剂的杂环化合物，并研究了它们的抑制活性。发现这些异噻唑烷-3-酮衍生物是组织蛋白酶G的有效抑制剂。
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