Siegmund W, Wölfle G, Franke G, Amon I
Department of Clinical Pharmacology, Medical Faculty, University of Greifswald, Fed. Rep. of Germany.
Arzneimittelforschung. 1993 Oct;43(10):1076-8.
Interactions of the cytoprotective agent nocloprost (9 beta-chloro-16,16-dimethyl-prostaglandin E2, CAS 79360-43-3) with the microsomal monooxygenase system were studied in rat and human liver. Nocloprost did neither bind to human and rat liver cytochrome P-450 nor changed the activities of aniline hydroxylase, aminopyrine demethylase, ethylmorphine N-demethylase, 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylase as well as 7-pentylresorufin O-depentylase after in vitro incubation with 1 ng/ml. Premedication of rats with 0.1 and 1.0 mg/kg lacked significant interferences with the monooxygenases studied.
在大鼠和人肝脏中研究了细胞保护剂诺氯前列素（9β-氯-16,16-二甲基-前列腺素E2，CAS 79360-43-3）与微粒体单加氧酶系统的相互作用。诺氯前列素既不与人及大鼠肝脏细胞色素P-450结合，在与1 ng/ml进行体外孵育后，也不改变苯胺羟化酶、氨基比林脱甲基酶、N-乙基吗啡脱甲基酶、7-乙氧基香豆素O-脱乙基酶、7-乙氧基试卤灵O-脱乙基酶以及7-戊基试卤灵O-脱戊基酶的活性。用0.1和1.0 mg/kg对大鼠进行预处理，对所研究的单加氧酶没有显著干扰。
