[Oxidative phosphorylation uncoupling by fatty acids in liver and muscle mitochondria].

Pathways and mechanisms of oxidative phosphorylation uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) uncoupling due to the low protonophoric activity of fatty acids.