Mokhova E N, Starkov A A, Bobyleva V A
Istituto di Patologia Generale, Universita degli Study di Modena, Italy.
Biokhimiia. 1993 Oct;58(10):1513-22.
Pathways and mechanisms of oxidative phosphorylation uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) uncoupling due to the low protonophoric activity of fatty acids.
本文探讨了长链脂肪酸在肝脏和肌肉线粒体中导致氧化磷酸化解偶联的途径和机制。得出的结论是，脂肪酸至少存在三种不同的解偶联途径，即：(i) 一种依赖Ca(2+)的环孢菌素A敏感途径；(ii) 被羧基苍术苷或其他ADP/ATP反向转运体抑制剂抑制的解偶联；(iii) 由于脂肪酸的低质子载体活性导致的解偶联。
