Shanks G D, Edstein M D, Kereu R K, Spicer P E, Rieckmann K H
Army Malaria Research Unit, Ingleburn, New South Wales, Australia.
Clin Infect Dis. 1993 Oct;17(4):628-31. doi: 10.1093/clinids/17.4.628.
Halofantrine was administered as prophylaxis for malaria to mine workers returning from endemic areas of Papua New Guinea. The men were randomly assigned to receive 500 mg of halofantrine daily for 3 days (n = 195) or 6 days (n = 150) or a total dose of 1,500 mg of chloroquine over 3 days (n = 55). None of the men receiving halofantrine developed falciparum malaria during the subsequent 28 days, whereas three men receiving chloroquine did develop this disease (P < .02). The administration of halofantrine after departure from an endemic area is one strategy for the prevention of falciparum malaria after short-term exposure.
卤泛群被用于对从巴布亚新几内亚疟疾流行地区返回的矿工进行疟疾预防。这些男性被随机分配，分别接受连续3天每天500毫克卤泛群（n = 195）、连续6天每天500毫克卤泛群（n = 150），或在3天内接受总量1500毫克氯喹（n = 55）。在随后的28天里，接受卤泛群的男性中无人患恶性疟，而接受氯喹的3名男性确实患上了这种疾病（P <.02）。离开流行地区后给予卤泛群是短期接触后预防恶性疟的一种策略。
