Frieden T R, Bia F J, Heald P W, Eisen R N, Patterson T F, Edelson R L
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Clin Infect Dis. 1993 Oct;17(4):776-8. doi: 10.1093/clinids/17.4.776.
Photopheresis is being used with increasing frequency as therapy for patients with neoplastic and dermatologic diseases and is being evaluated as therapy for patients with AIDS. We describe a patient with advanced cutaneous T cell lymphoma who developed pulmonary and cutaneous cryptococcosis after receiving therapy with photopheresis and biweekly methotrexate. We consider the potential roles of cutaneous T cell lymphoma, methotrexate, and photopheresis as predisposing factors in the development of serious cryptococcal infections.
光分离置换法作为治疗肿瘤和皮肤病患者的疗法，其使用频率日益增加，并且正在被评估作为治疗艾滋病患者的疗法。我们描述了一名晚期皮肤T细胞淋巴瘤患者，该患者在接受光分离置换法和每两周一次的甲氨蝶呤治疗后发生了肺和皮肤隐球菌病。我们考虑皮肤T细胞淋巴瘤、甲氨蝶呤和光分离置换法作为严重隐球菌感染发生的易感因素的潜在作用。
