Nakatani T, Anai H, Taenaka Y, Akagi H, Masuzawa T, Baba Y, Sakaki M, Araki K, Inoue K, Matsuo Y
National Cardiovascular Center Research Institute, Osaka, Japan.
ASAIO J. 1993 Jul-Sep;39(3):M644-8.
The authors developed an implantable left ventricular assist system (LVAS) for bridge to transplant of rather small sized adults. The pump was made of segmented polyether polyurethane and was 86 mm in diameter, 50 mm in height, with a 70 ml nominal stroke volume. A percutaneous drive line was connected with an external pneumatic control drive unit (CDU). In chronic animal experiments using 11 adult goats, the pump was installed between the LV apex and the descending aorta and was placed in the abdominal wall. Five goats were killed after 4 to 14 weeks while in good physical condition, and one is ongoing. There were no prominent thromboembolic symptoms despite no anti-thrombogenic agent being used. The new electrical impedance-based monitoring and control system (Z system) was installed in the CDU. In this Z system, automatic calibration was performed periodically for several seconds while the drive condition was changed to ensure full-fill of the blood pump. The full-fill to full-empty drive was well controlled by this Z system. In conclusion, the new Z system is practical and useful for monitoring and control of an implantable pump, giving this LVAS a promising place in clinical use.
作者研发了一种用于体型较小的成年人心脏移植过渡的可植入式左心室辅助系统（LVAS）。该泵由分段聚醚聚氨酯制成，直径86毫米，高50毫米，标称冲程容积为70毫升。经皮驱动线与外部气动控制驱动单元（CDU）相连。在使用11只成年山羊的慢性动物实验中，该泵安装在左心室心尖和降主动脉之间，并置于腹壁内。5只山羊在4至14周后身体状况良好时被处死，1只实验仍在进行中。尽管未使用抗血栓形成剂，但未出现明显的血栓栓塞症状。新的基于电阻抗的监测和控制系统（Z系统）安装在CDU中。在这个Z系统中，在驱动条件改变时会定期进行几秒钟的自动校准，以确保血泵充满血液。这种Z系统能很好地控制从充满到排空的驱动过程。总之，新的Z系统在监测和控制可植入泵方面实用且有效，使这种LVAS在临床应用中有广阔前景。
