Neugut A I, Santos J
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):551-3.
Malignant tumors of the small bowel are rare and little is known about their etiology, although adenocarcinomas share certain epidemiological features with colorectal cancer. This study investigated what cancers, if any, occurred as second neoplasms following adenocarcinomas, malignant carcinoid tumors, lymphomas, and sarcomas of the small bowel. For all 2581 cases of small bowel malignancy registered in one of the Surveillance, Epidemiology, and End-Results program areas, 1973-1988, the relative risk of a second malignancy was determined. The risk of colorectal cancer was increased following adenocarcinoma of the small bowel, and the risk of adenocarcinoma of the small bowel was increased following colorectal cancer in both males and females. This study also found an association between small bowel sarcomas and malignant melanoma in males, consistent with earlier studies, and an association between prostate cancer and malignant carcinoid tumors of the small bowel, a new observation. We conclude that adenocarcinomas of the small bowel may share risk factors with colorectal cancer.
小肠恶性肿瘤较为罕见，其病因鲜为人知，不过腺癌与结直肠癌有某些共同的流行病学特征。本研究调查了小肠腺癌、恶性类癌瘤、淋巴瘤和肉瘤之后作为第二肿瘤出现的是何种癌症（若有的话）。对于1973年至1988年期间在监测、流行病学和最终结果项目区之一登记的所有2581例小肠恶性肿瘤病例，确定了发生第二恶性肿瘤的相对风险。小肠腺癌之后患结直肠癌的风险增加，结直肠癌之后男性和女性患小肠腺癌的风险均增加。本研究还发现，男性小肠肉瘤与恶性黑色素瘤之间存在关联，这与早期研究一致，并且前列腺癌与小肠恶性类癌瘤之间存在关联，这是一项新发现。我们得出结论，小肠腺癌可能与结直肠癌有共同的风险因素。
