Suppr超能文献

脲酶试验与直接涂片检查在幽门螺杆菌感染治疗控制中的比较。

Comparison of the urease test and of direct smear examination in the control of treatment of Helicobacter pylori-induced infection.

作者信息

Resende L M, Queiroz D M, Mendes E N, Rocha G A, Coelho L G, Passos M C, Castro L P, Oliveira C A, Lima Júnior G F

机构信息

Departamento de Propedêutica Complementar, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

出版信息

Braz J Med Biol Res. 1993 Jul;26(7):699-702.

PMID:8268818
Abstract

The sensitivity and specificity of the preformed urease test and of carbolfuchsin-stained smears for the diagnosis of the presence of Helicobacter pylori in gastric mucosa were evaluated before and after antimicrobial treatment. The results obtained by culture were used as the reference point. We studied 41 patients with endoscopically diagnosed duodenal ulcer. Twenty-five of these were treated with furazolidone (100 mg t.i.d.), amoxicillin (500 mg t.i.d.) and metronidazole (250 mg t.i.d.) for 5 days and then with only furazolidone (100 mg t.i.d.) for an additional 25 days. The 16 control patients were treated with cimetidine (800 mg, 4 times a day). The sensitivity of the urease test and of direct smear examination was 100% before treatment and 84.6% and 92.3%, respectively, after treatment. We conclude that the urease test and carbolfuchsin-stained smears, which are highly sensitive for H. pylori diagnosis, present reduced sensitivity when they are employed for the follow-up of patients treated with antimicrobials.

摘要

在抗菌治疗前后,对预先形成的尿素酶试验和石炭酸复红染色涂片诊断胃黏膜中幽门螺杆菌存在情况的敏感性和特异性进行了评估。将培养获得的结果用作参考标准。我们研究了41例经内镜诊断为十二指肠溃疡的患者。其中25例患者接受了5天的呋喃唑酮(100毫克,每日三次)、阿莫西林(500毫克,每日三次)和甲硝唑(250毫克,每日三次)治疗,然后仅接受25天的呋喃唑酮(100毫克,每日三次)治疗。16例对照患者接受了西咪替丁(800毫克,每日四次)治疗。尿素酶试验和直接涂片检查的敏感性在治疗前为100%,治疗后分别为84.6%和92.3%。我们得出结论,尿素酶试验和石炭酸复红染色涂片对幽门螺杆菌诊断具有高度敏感性,但在用于接受抗菌治疗患者的随访时,其敏感性会降低。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验