Kiersch T A, Halladay S C, Koschik M
Associates in Oral and Maxillofacial Surgery, Tucson, Arizona.
Clin Ther. 1993 Sep-Oct;15(5):845-54.
In a double-blind, parallel, placebo-controlled study, 203 patients with post-operative dental pain following the extraction of one or two bony impacted third molars were randomized to receive a single dose of naproxen sodium 220 mg, ibuprofen 200 mg or placebo. Pain intensity and pain relief were assessed at intervals for 12 hours postdose. Both active drugs demonstrated superior analgesic efficacy over placebo. Naproxen sodium and ibuprofen were comparable both in onset of analgesic action and in pain relief. From 1 to 12 hours postdose, naproxen sodium showed a trend for superior analgesic efficacy compared with ibuprofen; this trend reached statistical significance at the 12-hour time point. Both drugs were well-tolerated and effective analgesics for postoperative dental pain.
在一项双盲、平行、安慰剂对照研究中，203例拔除一或两颗骨性阻生第三磨牙后出现术后牙痛的患者被随机分组，分别接受单剂量220毫克萘普生钠、200毫克布洛芬或安慰剂治疗。给药后12小时内定期评估疼痛强度和疼痛缓解情况。两种活性药物均显示出优于安慰剂的镇痛效果。萘普生钠和布洛芬在镇痛起效时间和疼痛缓解方面相当。给药后1至12小时，与布洛芬相比，萘普生钠显示出更强镇痛效果的趋势；这一趋势在12小时时间点达到统计学显著性。两种药物对术后牙痛均耐受性良好且镇痛有效。
