Koga Y
Psychopharmacology (Berl). 1976 Nov 10;50(2):153-7. doi: 10.1007/BF00430485.
Rats were intermittently medicated at one hour intervals through an implanted intravenous cannula. Physical dependence on morphine and codeine was developed rapidly and it was detectable with the maintenance dose as low as 9.6 mg/kg/day. Physical dependence on pentazocine was also developed with the maintenance dose of 96 mg/kg/day, but was not with 9.6 mg/kg/day. In the pentazocine-treated rates, body weight loss was observed after the abrupt withdrawal, and abstinence signs were precipitated by naloxone 1 mg/kg. Cross physical dependence between morphine and pentazocine was demonstrated. Pentazocine suppressed the abstinence signs of rats weakly dependent on morphine, and morphine suppressed those of pentazocine-dependent rats. ID-1229, a new benzomorphan analgesic, did not produce dependence in this test and did not suppress the abstinence signs of morphine- and pentazocine-dependent rats.
通过植入的静脉插管，每隔一小时对大鼠进行一次间歇性给药。大鼠对吗啡和可待因的身体依赖性迅速形成，维持剂量低至9.6毫克/千克/天时即可检测到。对喷他佐辛的身体依赖性也在维持剂量为96毫克/千克/天时形成，但在9.6毫克/千克/天时未形成。在接受喷他佐辛治疗的大鼠中，突然停药后观察到体重减轻，1毫克/千克的纳洛酮可引发戒断症状。证实了吗啡和喷他佐辛之间存在交叉身体依赖性。喷他佐辛对轻度依赖吗啡的大鼠的戒断症状有微弱抑制作用，吗啡对依赖喷他佐辛的大鼠的戒断症状也有抑制作用。新型苯并吗啡烷镇痛药ID - 1229在该试验中未产生依赖性，也未抑制吗啡和喷他佐辛依赖大鼠的戒断症状。
