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睡眠:右旋和左旋苯丙胺对人和大鼠的影响。

Sleep: effects of d- and l-amphetamine in man and in rat.

作者信息

Hartmann E, Cravens J

出版信息

Psychopharmacology (Berl). 1976 Nov 10;50(2):171-5. doi: 10.1007/BF00430488.

DOI:10.1007/BF00430488
PMID:826958
Abstract

Almost identical results are reported in man and in rat for the effects of the amphetamine isomers on polygraphically recorded sleep. In both species, dextro-amphetamine produces a significantly greater increase in waking time. In both species, the two isomers have equal effects in reducing desynchronized sleep time. These findings combined with other recent data suggest that dopamine plays a direct rolw in wakefulness while norepinephrine is related inversely to amolnts of desynchronized sleep.

摘要

关于苯丙胺异构体对多导睡眠图记录的睡眠的影响,在人类和大鼠中报告了几乎相同的结果。在这两个物种中,右旋苯丙胺使清醒时间显著增加。在这两个物种中,两种异构体在减少非同步睡眠时间方面具有相同的效果。这些发现与其他近期数据表明,多巴胺在清醒中起直接作用,而去甲肾上腺素与非同步睡眠量呈负相关。

相似文献

1
Sleep: effects of d- and l-amphetamine in man and in rat.睡眠:右旋和左旋苯丙胺对人和大鼠的影响。
Psychopharmacology (Berl). 1976 Nov 10;50(2):171-5. doi: 10.1007/BF00430488.
2
Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: a study of D- and L-derivatives in canine narcolepsy.多巴胺能机制在苯丙胺促醒作用中的意义:犬发作性睡病中D-和L-衍生物的研究
Neuroscience. 2000;99(4):651-9. doi: 10.1016/s0306-4522(00)00239-6.
3
The effects of neuroleptics with central dopamine and noradrenaline receptor blocking properties in the L-DOPA and (+)-amphetamine-induced waking EEG in the rat.具有中枢多巴胺和去甲肾上腺素受体阻断特性的抗精神病药物对大鼠左旋多巴和(+)-苯丙胺诱导的清醒脑电图的影响。
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4
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Science. 1970 Jun 19;168(3938):1487-9. doi: 10.1126/science.168.3938.1487.
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Psychopharmacologia. 1969;14(5):359-70. doi: 10.1007/BF00403576.

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本文引用的文献

1
The effects of dextro-amphetamine on behavioral deficits produced by sleep loss in humans.右旋苯丙胺对人类睡眠剥夺所致行为缺陷的影响。
J Pharmacol Exp Ther. 1959 Sep;127:46-50.
2
EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H3-NOREPINEPHRINE IN THE RAT BRAIN.药物对大鼠脑中H3-去甲肾上腺素摄取、释放及代谢的影响
J Pharmacol Exp Ther. 1965 Jul;149:43-9.
3
[EFFECTS OF RESERPINE, DOPA AND 5-HTP ON THE 2 SLEEP STATES].[利血平、多巴和5-羟色胺对两种睡眠状态的影响]
苯丙胺和戊巴比妥对伴有基底前脑损伤的猫的睡眠-觉醒模式的影响。
Psychopharmacology (Berl). 1980;68(2):179-84. doi: 10.1007/BF00432138.
4
Strain differences in amphetamine sensitivity in mice. II. Overcompensation of paradoxical sleep after deprivation in two C57 strains.小鼠对苯丙胺敏感性的品系差异。II. 两种C57品系剥夺后异相睡眠的过度补偿
Psychopharmacology (Berl). 1979;66(3):291-5. doi: 10.1007/BF00428322.
5
The effects of neuroleptics with central dopamine and noradrenaline receptor blocking properties in the L-DOPA and (+)-amphetamine-induced waking EEG in the rat.具有中枢多巴胺和去甲肾上腺素受体阻断特性的抗精神病药物对大鼠左旋多巴和(+)-苯丙胺诱导的清醒脑电图的影响。
Br J Pharmacol. 1979 Sep;67(1):87-91.
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THE EFFECT OF AMPHETAMINE ON THE SLEEP CYCLE.安非他明对睡眠周期的影响。
Electroencephalogr Clin Neurophysiol. 1964 May;16:438-45. doi: 10.1016/0013-4694(64)90086-0.
5
EXCITABILITY CHANGES DURING THE SLEEP CYCLE OF THE RAT.大鼠睡眠周期中的兴奋性变化。
Electroencephalogr Clin Neurophysiol. 1963 Oct;15:775-85. doi: 10.1016/0013-4694(63)90168-8.
6
Enhancement of human performance by caffeine and the amphetamines.咖啡因和安非他明对人类机能的增强作用。
Pharmacol Rev. 1962 Mar;14:1-36.
7
Effect of alpha-methyltyrosine on sleep in the rat.α-甲基酪氨酸对大鼠睡眠的影响。
Percept Mot Skills. 1967 Dec;25(3):805-8. doi: 10.2466/pms.1967.25.3.805.
8
Evidence that the central action of amphetamine is mediated via catecholamines.有证据表明苯丙胺的中枢作用是通过儿茶酚胺介导的。
Psychopharmacologia. 1966;9(1):78-80. doi: 10.1007/BF00427706.
9
Reserpine: its effect on the sleep-dream cycle in man.
Psychopharmacologia. 1966;9(3):242-7. doi: 10.1007/BF02198484.
10
Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.关于丙咪嗪类药物和(+)-苯丙胺对中枢和外周儿茶酚胺能神经元作用的生化与组织化学研究。
Acta Physiol Scand. 1966 Jul-Aug;67(3):481-97. doi: 10.1111/j.1748-1716.1966.tb03334.x.