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情绪障碍中的单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)成像

SPECT and PET imaging in mood disorders.

作者信息

George M S, Ketter T A, Post R M

机构信息

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. 20892.

出版信息

J Clin Psychiatry. 1993 Nov;54 Suppl:6-13.

PMID:8270597
Abstract

Single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies are yielding a picture of clinical depression as a disorder associated with dysfunction in specific brain regions. These data support the view of depression as a disease of the brain in general and of the frontal and temporal lobes in particular. Frontal lobe hypometabolism is emerging as a common final pathway for most types of primary and secondary depression, regardless of the original cause. The severity of depression is often related to the degree of frontal hypometabolism, and preliminary studies indicate that the hypometabolism normalizes after treatment in concert with the patient's improved mood. Primary depression also is associated with abnormal activation of key brain areas, including discrete aspects of the frontal and temporal lobes, the amygdala, and the cingulate gyrus. Several areas of research are currently under way using SPECT or PET to explore further the neuroanatomy of depression.

摘要

单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)研究正在呈现出一幅临床抑郁症的图景,即一种与特定脑区功能障碍相关的疾病。这些数据支持了抑郁症总体上是一种脑部疾病,尤其是额叶和颞叶疾病的观点。额叶代谢减退正成为大多数原发性和继发性抑郁症的常见最终通路,无论其最初病因如何。抑郁症的严重程度通常与额叶代谢减退的程度相关,初步研究表明,治疗后代谢减退会随着患者情绪的改善而恢复正常。原发性抑郁症还与关键脑区的异常激活有关,包括额叶和颞叶的离散区域、杏仁核和扣带回。目前正在进行几个研究领域,使用SPECT或PET进一步探索抑郁症的神经解剖学。

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