Mitchell A R, Nicol L, Malloy P, Kipling D
MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, UK.
J Cell Sci. 1993 Sep;106 ( Pt 1):79-85. doi: 10.1242/jcs.106.1.79.
Chromosome 1 of the inbred mouse strain DBA/2 shows an unusual polymorphism associated with its centromeric satellite DNA sequences. The minor satellite array has undergone amplification and is present as two blocks separated by major satellite sequences. Both minor satellite blocks appear to carry the sequence motif necessary for CENP-B protein binding. Despite this apparent similarity the functional centromere, as defined by the location of CREST antigens, appears to form only within the more terminal block. The two blocks also vary in that sister chromatid association only occurs with this more terminal block.
近交系小鼠DBA/2的1号染色体显示出与其着丝粒卫星DNA序列相关的异常多态性。较小的卫星阵列发生了扩增，以两个被主要卫星序列隔开的区域形式存在。两个较小的卫星区域似乎都携带CENP-B蛋白结合所需的序列基序。尽管有这种明显的相似性，但由CREST抗原的位置所定义的功能着丝粒似乎仅在更靠近末端的区域内形成。这两个区域的另一个不同之处在于，姐妹染色单体联会仅发生在这个更靠近末端的区域。
