Miwa C, Sawatari S
Gifu Prefectural Health and Environment Research Center.
Kansenshogaku Zasshi. 1993 Nov;67(11):1068-75. doi: 10.11150/kansenshogakuzasshi1970.67.1068.
During July to December in 1991, an epidemic of aseptic meningitis occurred in Gifu Prefecture in children. Epidemiological, virological and serological investigations were performed. The results are as follows: 1) Cases involved ranged from 0 to 13 years of age, and 75.9% of them were in the 3 to 7 year of age group. 2) Three types of enteroviruses were isolated from 83 of 133 cases (62.4%), and the echovirus type 30 was recovered from 71 cases (85.5%). 3) In 1991 with the cross neutralizing test between the prototype and isolated strains of echovirus type 30, a remarkable antigenic variation could not be found. 4) In serological studies, the positive rates of neutralizing antibodies to echovirus type 30 in infant sera aged 0-9 years in 1992-1993, was 51.9% with the prototype strain, but 34.0% with an isolated strain in 1991.
1991年7月至12月期间，岐阜县儿童中发生了无菌性脑膜炎流行。进行了流行病学、病毒学和血清学调查。结果如下：1）病例年龄范围为0至13岁，其中75.9%在3至7岁年龄组。2）从133例中的83例（62.4%）分离出三种肠道病毒，71例（85.5%）分离出埃可病毒30型。3）在1991年对埃可病毒30型原型株和分离株进行交叉中和试验时，未发现明显的抗原变异。4）在血清学研究中，1992 - 1993年0至9岁婴儿血清中对埃可病毒30型中和抗体的阳性率，以原型株计为51.9%，但以1991年的分离株计为34.0%。
