[Immunological efficacy of live streptomycin-dependent salmonellae vaccines used orally in experiment on monkeys].

Experiments were conducted on 99 monkeys; a study was made of the reactogenic properties and the immunological efficacy of the streptomycin-dependent S. enteritidis and S. typhimurium mutants in oral application. The results of clinical, bacteriological, pathomorphological and fluorescent-serological studies demonstrated that the vaccines in the doses under study were areactogenic for monkeys in 5-fold oral administration and promoted development of marked immunity. The greatest immunizing effect was obtained in 5-fold oral vaccination with the subsequent three-fold (in 2 months) revaccination of the monkeys. Associated streptomyqin-dependent S. enteritidis and S. typhimurium vaccine could be used for prophylaxis of salmonellosis in monkeys.