1例采用两性霉素B腔内注射联合乌司他丁静脉给药治疗成功的肺曲菌球病例

[A case of pulmonary aspergilloma successfully treated with combination therapy of intracavitary injection of amphotericin B and intravenous administration of urinastatin].

作者信息

Maesaki S, Kohno S, Tanaka K, Miyazaki H, Mitsutake K, Miyazaki T, Tomono K, Kaku M, Koga H, Hara K

机构信息

Second Department of Internal Medicine, Nagasaki University School of Medicine.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Oct;31(10):1327-31.

PMID:8271670

Abstract

A 57-year-old man with pulmonary tuberculosis underwent left upper lobectomy in 1984. In 1987, chest X-ray showed a fungus ball, and Aspergillus species was isolated from sputum. He was treated by intracavitary injection of amphotericin B (AMPH) in June, 1992. However, no change was observed in the chest CT scan after a total dose of 1,000 mg of AMPH. Combination therapy of intravenous administration of 100,000 units of urinastatin and intracavitary injection of AMPH resulted in complete disappearance of the fungus ball on chest CT scan. This report describes case of pulmonary aspergilloma successfully treated with the combination of AMPH and urinastatin.

摘要

一名57岁的肺结核男性患者于1984年接受了左上肺叶切除术。1987年，胸部X线显示有真菌球，痰中分离出曲霉菌。1992年6月，他接受了两性霉素B（AMPH）腔内注射治疗。然而，在总剂量达1000mg的AMPH治疗后，胸部CT扫描未见变化。静脉注射100000单位乌司他丁联合AMPH腔内注射治疗后，胸部CT扫描显示真菌球完全消失。本报告描述了1例通过AMPH和乌司他丁联合治疗成功治愈的肺曲菌球病例。