Weinberg H, Zhang W X, Urken M L
Department of General Surgery, Mount Sinai Medical Center, New York, NY 10029.
Microsurgery. 1993;14(8):537-40. doi: 10.1002/micr.1920140811.
UW solution has been found to be an effective organ perfusate for transplantation. Initial studies in experimental pedicle skin flaps have also demonstrated its unique effectiveness in prolonged ischemia. To understand better the limits of its preservation properties without the influence of endothelial clamp damage, we have undertaken to study the properties of UW solution in experimental microvascular free flaps. Control, lactated Ringer's, and UW solutions were utilized in pedicle and microvascular free flaps in Sprague-Dawley rats over varying periods of ischemia. UW solution demonstrated a clear superiority over all other solutions in both flap models. In addition there also was a significant prolongation of critical ischemia time in UW-treated free flaps compared to pedicle flaps.
UW液已被证明是一种有效的移植器官灌注液。最初在实验性带蒂皮瓣中的研究也表明，它在延长缺血时间方面具有独特的有效性。为了在不受内皮夹损伤影响的情况下更好地了解其保存特性的局限性，我们着手研究UW液在实验性游离微血管皮瓣中的特性。在不同缺血时间内，将对照液、乳酸林格液和UW液应用于斯普拉格-道利大鼠的带蒂皮瓣和游离微血管皮瓣。在两种皮瓣模型中，UW液均显示出明显优于所有其他溶液的效果。此外，与带蒂皮瓣相比，经UW处理的游离皮瓣的临界缺血时间也显著延长。
