血液透析患者中的抗丙型肝炎病毒抗体和丙型肝炎病毒血症

Anti-hepatitis C virus antibodies and hepatitis C virus viraemia in haemodialysis patients.

作者信息

Picciotto A, Varagona G, Gurreri G, Fiorini F, Sofia A, Coviello D A, Bonanni P, Icardi G C, Valle F, Celle G

机构信息

Department of Internal Medicine, University of Genoa, Italy.

出版信息

Nephrol Dial Transplant. 1993;8(10):1115-7.

PMID:8272226

Abstract

Sera from 82 haemodialysis patients were tested for anti-HCV, HCV-RNA, and HBsAg. Alanine aminotransferase (ALT) activity was monitored weekly for 2 months. Anti-HCV was positive in 31 patients (37.8%), showing different single-peptide patterns. HCV-RNA was detected in 26 anti-HCV-positive patients (84%) and also in two of 21 anti-HCV-negative patients. Twenty-seven (87%) of the 31 anti-HCV-positive patients had persistently normal ALT values; 22 of these patients were HCV-RNA positive. The four patients with elevated ALT values had HCV viraemia. HBsAg was positive in nine anti-HCV-negative patients. The close correlation between HCV viraemia and HCV status, independently of ALT values, requires that anti-HCV dialysis patients must be considered potentially infective and dialysed with reserved machines and/or in separate shifts.

摘要

对82例血液透析患者的血清进行了抗丙型肝炎病毒（anti-HCV）、丙型肝炎病毒核糖核酸（HCV-RNA）和乙型肝炎表面抗原（HBsAg）检测。连续2个月每周监测丙氨酸转氨酶（ALT）活性。31例患者（37.8%）抗-HCV呈阳性，表现出不同的单肽模式。在26例抗-HCV阳性患者（84%）以及21例抗-HCV阴性患者中的2例中检测到HCV-RNA。31例抗-HCV阳性患者中有27例（87%）ALT值持续正常；其中22例患者HCV-RNA呈阳性。4例ALT值升高的患者存在HCV病毒血症。9例抗-HCV阴性患者HBsAg呈阳性。HCV病毒血症与HCV状态之间的密切相关性，与ALT值无关，这要求必须将抗-HCV透析患者视为潜在感染者，并使用备用机器和/或在单独班次进行透析。