Falkenhagen D, Brown G S, Thomaneck U, Levin N W, Ivanovich P, Bergstrom J, Kishimoto T, Klinkmann H
Department of Internal Medicine, University of Rostock, Germany.
Nephrol Dial Transplant. 1993;8 Suppl 2:8-14. doi: 10.1093/ndt/8.supp2.8.
Seven different types of dialysers were investigated in five dialysis centres in four countries with respect to behaviour of white blood cells and the complement system. The results of this controlled crossover study demonstrated significant differences in the dialysers. Those containing cuprammonium cellulose (G10-3N and G120 M) showed the greatest changes in white blood cell count, including monocytes and neutrophils, as well as the greatest complement activation. With regard to lymphocytes the subpopulation of low-mobility cells, which were predominantly the B-cells, showed the greatest mobility with dialysers containing cuprammonium cellulose. The PAN copolymer- and PMMA-containing dialysers Filtral and T 150 clearly caused the least changes in white blood cells and complement factors. Dialysers containing cellulose acetate and polysulphone membranes (Duo-Flux Artificial Kidney, CD 4000, and F 60) produced only a moderate decrease of WBC, monocyte, neutrophil, and lymphocyte counts, and this result corresponded to a relatively small change in complement factors.
在四个国家的五个透析中心，针对七种不同类型的透析器对白细胞和补体系统的影响进行了研究。这项对照交叉研究的结果表明，不同透析器之间存在显著差异。含有铜氨纤维素的透析器（G10 - 3N和G120 M）在白细胞计数（包括单核细胞和中性粒细胞）方面变化最大，补体激活程度也最高。对于淋巴细胞，低迁移率细胞亚群（主要是B细胞）在含有铜氨纤维素的透析器中迁移率变化最大。含有PAN共聚物和PMMA的透析器Filtral和T 150对白细胞和补体因子的影响明显最小。含有醋酸纤维素和聚砜膜的透析器（Duo - Flux人工肾、CD 4000和F 60）仅使白细胞、单核细胞、中性粒细胞和淋巴细胞计数适度下降，这一结果与补体因子相对较小的变化相对应。
