Suleman F G, Ghersi-Egea J F, Leininger-Muller B, Minn A
Centre du Médicament, URA CNRS 597, Nancy, France.
Neurosci Lett. 1993 Oct 29;161(2):219-22. doi: 10.1016/0304-3940(93)90298-y.
The glucuronidation capacity of rat brain microsomes was investigated using a series of chemically related phenolic compounds and fatty acids which are usually glucuronidated in vivo. Most of the phenols assayed were glucuronidated, but no glucuronide formation was detected for stearic and alpha-linolenic acids, 4-methylphenol, bilirubin, morphine, dopamine and serotonin. The activity of uridine diphosphate-glucuronosyltransferase (UGT) towards 1-naphthol represented 0.28% of that obtained with liver microsomes. The inhibitory effects on the formation of 1-naphthol glucuronide of some endogenous and exogenous substances were investigated. The results suggest that only the isoform of UGT conjugating 1-naphthol is present in rat brain.
利用一系列通常在体内进行葡萄糖醛酸化的化学相关酚类化合物和脂肪酸，对大鼠脑微粒体的葡萄糖醛酸化能力进行了研究。所检测的大多数酚类都发生了葡萄糖醛酸化，但未检测到硬脂酸、α-亚麻酸、4-甲基苯酚、胆红素、吗啡、多巴胺和血清素形成葡萄糖醛酸苷。尿苷二磷酸葡萄糖醛酸基转移酶（UGT）对1-萘酚的活性仅为肝微粒体活性的0.28%。研究了一些内源性和外源性物质对1-萘酚葡萄糖醛酸苷形成的抑制作用。结果表明，大鼠脑中仅存在与1-萘酚结合的UGT同工型。
