蛋白质 - 热量营养不良中的分泌型免疫球蛋白A
Secretory IgA in protein-calorie malnutrition.
作者信息
Reddy V, Raghuramulu N, Bhaskaram C
出版信息
Arch Dis Child. 1976 Nov;51(11):871-4. doi: 10.1136/adc.51.11.871.
Abstract
The secretory IgA system was investigated in children with protein-calorie malnutrition (PCM). The results of the study indicated that in children suffering from kwashiorkor and marasmus the concentration of IgA in duodenal fluid, saliva, nasal secretions, and tears was significantly reduced on admission and returned to normal 4 weeks after treatment. However, the concentration of secretory IgA in children with mild to moderate PCM was similar to that of normal children. Secretory IgA deficiency may be an important factor in promoting bacterial growth and this may account for the increased incidence and severity of mucosal infections in children with severe PCM.
摘要
对蛋白质-热量营养不良（PCM）患儿的分泌型IgA系统进行了研究。研究结果表明，患夸希奥科病和消瘦症的患儿入院时十二指肠液、唾液、鼻分泌物和泪液中的IgA浓度显著降低，治疗4周后恢复正常。然而，轻度至中度PCM患儿的分泌型IgA浓度与正常儿童相似。分泌型IgA缺乏可能是促进细菌生长的一个重要因素，这可能解释了重度PCM患儿黏膜感染发生率和严重程度增加的原因。
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