Harms M, Olmos L, Hunziker N, Laugier P
Arch Dermatol Res (1975). 1976 Dec 15;257(2):131-42. doi: 10.1007/BF00558086.
After topical application of the carcinogen DMBA on the rabbit's ear, tumors will always appear. These are clinically characterized by their important hyperkeratosis. Some of these tumors develop rapidly and disappear completely as do KA. Others do not reach such an important size but do not regress. None of these tumors looked like a malignant tumor and did not show signs of invasiveness nor metastasis. However the histological findings reveal in some cases precancerous and malignant aspects. The number of tumors can be increased by lengthening the application time of the carcinogen, by modifying the mode of application (repeated application and transport medium DMSO) and by irradiation.
