Günther W, Giunta R, Klages U, Haag C, Steinberg R, Satzger W, Jonitz L, Engel R
Department of Psychiatry, Nervenklinik, Bamberg, Germany.
Psychiatry Res. 1993 Oct;50(3):163-76. doi: 10.1016/0925-4927(93)90028-g.
Sixteen-channel electroencephalographic (EEG) brain mapping studies were carried out under resting conditions in 41 patients with mild to moderate dementia of the Alzheimer type, diagnosed according to DSM-III-R criteria. The patients showed diffuse patterns of EEG slowing, as known from the literature. They showed increases of theta power in large bilateral brain areas and bitemporal increases of delta power as compared with both age-matched and younger control subjects. In addition, the patients had increased beta activity in comparison with the younger control group, but not with the age-matched control subjects. Functional brain mapping revealed decreases of EEG power during manual-motor and music-perception tasks in delta frequencies for patients, which was not seen in either of the two control groups. All frequency bands revealed major gender-related differences in EEG activity, which should receive more attention in future research.
根据DSM-III-R标准，对41例轻度至中度阿尔茨海默型痴呆患者在静息状态下进行了16通道脑电图（EEG）脑图谱研究。正如文献中所知，患者表现出脑电图减慢的弥漫性模式。与年龄匹配和较年轻的对照组相比，他们在双侧大脑大面积区域的θ波功率增加，双侧颞叶的δ波功率增加。此外，与较年轻的对照组相比，患者的β活动增加，但与年龄匹配的对照组相比则没有。功能性脑图谱显示，患者在手动运动和音乐感知任务期间，δ频率的脑电图功率下降，而两个对照组均未出现这种情况。所有频段在脑电图活动中均显示出与性别相关的主要差异，这在未来的研究中应得到更多关注。
