Metaphyseal abnormalities in children: pathophysiology and radiologic appearance.

The most active site of formation of bone in children is the metaphysis. Systemic and local diseases are reflected by alterations in the morphology of this region. In this pictorial essay, we examine several patterns of metaphyseal abnormalities seen on radiologic images and review the associated pathophysiology. Differential diagnosis may be aided by considering the pathologic mechanisms responsible for the various metaphyseal alterations.