Trappe H J, Klein H, Wahlers T, Fieguth H G, Wenzlaff P, Kielblock B, Lichtlen P R
Department of Cardiology, University Hospital Hannover, p5rmany.
Am Heart J. 1994 Jan;127(1):75-82. doi: 10.1016/0002-8703(94)90512-6.
It is unclear whether additional aortocoronary bypass grafting should be performed in patients who need an automatic implantable cardioverter defibrillator (ICD) in one- or two-step procedures. Therefore we studied the follow-up of 139 patients who underwent epicardial implantation of the cardioverter defibrillator (CD). All patients had coronary artery disease and recurrent ventricular tachycardia or fibrillation. Eighty-nine patients had implantation of the CD without additional surgical approaches (group G1), and 50 patients had concomitant aortocoronary bypass grafting (group G2). Perioperative mortality (within 30 days after CD implant) was 1 (1%) of 89 patients in G1 and 6 (12%) of 50 patients in G2 (p < 0.01). During the mean follow-up of 26 +/- 20 months, sudden death occurred in four (4%) of 89 patients in G1 and two (4%) of 50 patients in G2. Twenty-three (17%) patients died of cardiac failure (18 [20%] patients in G1 and 5 [10%] patients in G2). ICD discharges occurred in 69 (78%) of 89 patients in G1 and in 36 (72%) of 50 patients in G2. The mean incidence of ICD discharges was 23 +/- 69 shocks per patient in G1 and 18 +/- 25 shocks per patient in G2 (p = NS). We conclude that concomitant aortocoronary bypass grafting during CD implantation leads to a higher perioperative mortality. Avoidance of myocardial ischemia does not significantly influence sudden death mortality nor markedly reduce the number of ICD discharges.
对于那些需要植入自动植入式心脏复律除颤器(ICD)的患者,是否应分一步或两步进行额外的主动脉冠状动脉搭桥术尚不清楚。因此,我们对139例行心外膜植入心脏复律除颤器(CD)的患者进行了随访。所有患者均患有冠状动脉疾病且有复发性室性心动过速或颤动。89例患者植入了CD,未采用额外的手术方法(G1组),50例患者同时进行了主动脉冠状动脉搭桥术(G2组)。围手术期死亡率(CD植入后30天内)在G1组的89例患者中为1例(1%),在G2组的50例患者中为6例(12%)(p<0.01)。在平均26±20个月的随访期间,G1组的89例患者中有4例(4%)猝死,G2组的50例患者中有2例(4%)猝死。23例(17%)患者死于心力衰竭(G1组18例[20%],G2组5例[10%])。G1组的89例患者中有69例(78%)发生ICD放电,G2组的50例患者中有36例(72%)发生ICD放电。G1组患者ICD放电的平均发生率为每人23±69次电击,G2组为每人18±25次电击(p=无显著性差异)。我们得出结论,CD植入期间同时进行主动脉冠状动脉搭桥术会导致较高的围手术期死亡率。避免心肌缺血对猝死死亡率没有显著影响,也没有明显减少ICD放电次数。