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肿瘤免疫即自身免疫：肿瘤抗原包括可刺激无反应性外周T细胞的正常自身蛋白。

Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T cells.

作者信息

Parmiani G

机构信息

Division of Experimental Oncology D, National Tumor Institute, Milan, Italy.

出版信息

Immunol Today. 1993 Nov;14(11):536-8. doi: 10.1016/0167-5699(93)90183-L.

DOI:10.1016/0167-5699(93)90183-L
PMID:8274196
Abstract

Oncogenic transformation is often accompanied by a significant overproduction of otherwise normal cellular proteins. Because of the low expression of such self components during thymic development, T cells specific for these antigens can escape deletion and progress to the periphery. In this viewpoint, Giorgio Parmiani discusses the concept that these T cells can be harnessed to provide an effective anti-tumor response.

摘要

致癌转化通常伴随着原本正常的细胞蛋白大量过度产生。由于这些自身成分在胸腺发育过程中表达水平较低，针对这些抗原的T细胞能够逃脱清除并进入外周。从这个角度来看，乔治·帕尔米尼讨论了利用这些T细胞来提供有效抗肿瘤反应的概念。

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