Novikov V E, Iasnetsov V V
Biull Eksp Biol Med. 1993 Aug;116(8):125-7.
Experiments in rats showed i. p. injections of a dose of 0.1 mg/kg of highly mu-selective agonist DAGO, relatively selective delta-receptor agonist DSLET and Tyr-D-Ala-Gly-MePhe-Leu-Arg-NH-Et to attenuate markedly the development of cerebral edema 24 hours after brain injury. The same effect was found with administration of DSLET 4 days after trauma. Naloxone (1 mg/kg, i. p.) had no effect on this process, but completely blocked protective effect of peptides. These data demonstrate that both mu and delta opioid receptors are involved in the pathogenesis of traumatic cerebral edema.
对大鼠进行的实验表明，腹腔注射剂量为0.1毫克/千克的高μ选择性激动剂DAGO、相对选择性δ受体激动剂DSLET以及Tyr-D-Ala-Gly-MePhe-Leu-Arg-NH-Et，可显著减轻脑损伤后24小时脑水肿的发展。在创伤后4天给予DSLET也发现了同样的效果。纳洛酮（1毫克/千克，腹腔注射）对这一过程没有影响，但完全阻断了肽类的保护作用。这些数据表明，μ和δ阿片受体均参与创伤性脑水肿的发病机制。
