[实验性心肌梗死时主动脉壁一氧化氮合成的增强]
[The intensification of nitric oxide synthesis in the aortic wall in experimental myocardial infarct].
作者信息
Vanin A F, Manukhina E B, Lapshin A V, Meerson F Z
出版信息
Biull Eksp Biol Med. 1993 Aug;116(8):142-4.
The effect of experimental myocardial infarction on endothelium-dependent relaxation of isolated rat aorta and generation of nitric oxide in the aortic wall was studied. Three hours following myocardial infarction, the endothelium-dependent relaxation induced with acetylcholine was increased to 61 +/- 2% as compared with 41 +/- 4% in control (r < 0.05). The nitric oxide generation (EPR-assay) was 2.5 times increased in the aortic wall of animals subjected to myocardial infarction as compared with the control. The activated generation of nitric oxide may be provoked by the reduced minute volume of the heart and concomitant transient hypovolemia.
研究了实验性心肌梗死对离体大鼠主动脉内皮依赖性舒张及主动脉壁一氧化氮生成的影响。心肌梗死后3小时，乙酰胆碱诱导的内皮依赖性舒张与对照组的41±4%相比增加至61±2%（r<0.05）。与对照组相比，心肌梗死动物主动脉壁中的一氧化氮生成（电子顺磁共振测定法）增加了2.5倍。心脏每分输出量减少和随之而来的短暂性血容量不足可能会引发一氧化氮的激活生成。
Zotero 插件