Du X X, Doerschuk C M, Orazi A, Williams D A
Herman B. Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, IN.
Blood. 1994 Jan 1;83(1):33-7.
The proliferation of epithelial cells lining the small intestinal mucosa may be regulated by microenvironmental signals leading to differentiation of precursor cells in the small intestinal crypts. Proliferation of hematopoietic cells within the hematopoietic microenvironment is known to be regulated by a growing number of glycoprotein growth factors in a hierarchial fashion. We studied the effects of administration of the microenvironment-derived hematopoietic growth factor interleukin-11 (IL-11) on mice given combination radiation/chemotherapy. Treatment of such mice with IL-11 led to significantly increased survival and evidence of rapid recovery of the small intestinal mucosa, which is severely damaged by these cytoxic agents. This recovery was associated with an increase in the mitotic index of crypt cells and an increased frequency of staining of these cells with a monoclonal antibody to proliferating cell nuclear antigen, a member of the cyclin family of nuclear antigens.
小肠黏膜上皮细胞的增殖可能受微环境信号调控，这些信号可促使小肠隐窝中的前体细胞分化。已知造血微环境中造血细胞的增殖受越来越多糖蛋白生长因子以分级方式调控。我们研究了给予微环境来源的造血生长因子白细胞介素-11（IL-11）对接受联合放疗/化疗小鼠的影响。用IL-11治疗此类小鼠可显著提高存活率，并显示小肠黏膜迅速恢复，而小肠黏膜因这些细胞毒性药物受到严重损伤。这种恢复与隐窝细胞有丝分裂指数增加以及这些细胞被一种针对增殖细胞核抗原（细胞周期蛋白家族核抗原成员）的单克隆抗体染色频率增加有关。
