Azón-Masoliver A, Vilaplana J
Department of Dermatology, Hospital de Sant Joan, Reus, Spain.
Dermatology. 1993;187(4):268-9. doi: 10.1159/000247261.
Patients with human immunodeficiency virus (HIV) infection are prone to severe drug reactions, mainly from sulfonamides. We report the case of a 33-year-old male patient with HIV infection (group IV C-2 of CDC staging system) that developed a toxic epidermal necrolysis (TEN) affecting more than 70% of the body surface area and severe mucosal involvement after starting fluconazole for a recurrent oral thrush with dysphagia. This is to our knowledge the first reported case of TEN due to fluconazole.
感染人类免疫缺陷病毒（HIV）的患者容易发生严重药物反应，主要源于磺胺类药物。我们报告一例33岁男性HIV感染患者（疾病控制与预防中心分期系统IV C-2组），该患者因复发性口腔念珠菌病伴吞咽困难开始使用氟康唑后，发生了中毒性表皮坏死松解症（TEN），累及身体表面积超过70%，并伴有严重的黏膜受累。据我们所知，这是首例因氟康唑导致TEN的报告病例。
