酵母和哺乳动物线粒体DNA复制的保守特征。

Conserved features of yeast and mammalian mitochondrial DNA replication.

作者信息

Schmitt M E, Clayton D A

机构信息

Department of Developmental Biology, Stanford University School of Medicine, California 94305-5427.

出版信息

Curr Opin Genet Dev. 1993 Oct;3(5):769-74. doi: 10.1016/s0959-437x(05)80097-8.

DOI:10.1016/s0959-437x(05)80097-8

PMID:8274861

Abstract

Mammalian mitochondrial DNA replication is initiated by the processing of RNA transcripts derived from an upstream promoter to create RNA primers for DNA replication. In the yeast Saccharomyces cerevisiae, mitochondrial ori/rep sequences contain a transcription promoter upstream of the site of transition from RNA to DNA synthesis, suggesting a common mode of replication initiation. Recent research has identified features in the mode and machinery of DNA replication conserved from yeast to mammals.

摘要

哺乳动物线粒体DNA复制是通过加工来自上游启动子的RNA转录本以产生用于DNA复制的RNA引物来启动的。在酵母酿酒酵母中，线粒体ori/rep序列在从RNA合成转变为DNA合成的位点上游含有一个转录启动子，这表明存在一种共同的复制起始模式。最近的研究已经确定了从酵母到哺乳动物在DNA复制模式和机制方面保守的特征。