Di Masso R J, Font M T
Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Bone Miner. 1993 Oct;23(1):49-56. doi: 10.1016/s0169-6009(08)80090-6.
Bone mineral content was investigated in 2 lines of mice (CBi/C and CBi/L) that carry different biomasses per unit of skeletal weight. These lines also differ in their femoral histomorphometry and bone biomechanics. The logarithmic form of the allometric equation describing the relationship between ash weight and body weight was used to compare the mineral content in both sexes of these genotypes. No statistical difference was observed in the slopes of the curves describing the changes in bone mineral content as a function of age. Both lines had greater values than the line for control animals. The selected lines did differ significantly in the intercepts of the curves on the y-axis. An independent determination of both allometric parameters by genetic factors is proposed. Genes or groups of genes could affect mineral deposition in two ways: one could produce positional changes of the allometric curves in the embryo but leave their postnatal slopes unchanged; another could modify the postnatal slope of the curve. The combined expression of these different genes should be important in preserving homeostatic functioning of the organism.
对两系小鼠（CBi/C和CBi/L）的骨矿物质含量进行了研究，这两系小鼠每单位骨骼重量的生物量不同。这些品系在股骨组织形态计量学和骨生物力学方面也存在差异。描述灰重与体重之间关系的异速生长方程的对数形式被用于比较这些基因型两性的矿物质含量。在描述骨矿物质含量随年龄变化的曲线斜率上未观察到统计学差异。两系小鼠的值均高于对照动物品系。所选品系在曲线与y轴的截距上确实存在显著差异。有人提出由遗传因素对这两个异速生长参数进行独立测定。基因或基因群可能通过两种方式影响矿物质沉积：一种可能在胚胎期产生异速生长曲线的位置变化，但出生后的斜率不变；另一种可能改变出生后曲线的斜率。这些不同基因的联合表达对于维持机体的稳态功能应该很重要。
