Raghu B, Sarma G R, Venkatesan P
Department of Biochemistry, Tuberculosis Research Centre, (Indian Council of Medical Research), Madras.
Biochem Mol Biol Int. 1993 Oct;31(2):341-8.
To gain a better understanding of the role of iron in the pathogenesis of tuberculosis, the growth and production of siderophores were studied in the presence of different concentrations of free iron in vitro with M. smegmatis and virulent, avirulent and low virulent strains of M. tuberculosis. Increase in the concentrations of iron caused an appreciable increase in the growth (as assessed by cell dry-weight and log viable counts) of all 4 strains. This was, however accompanied by a significant decrease in the production of both exochelins and mycobactins, suggesting that these siderophores are necessary only under iron-deficient conditions. The growth and production of siderophores were significantly higher with the virulent strain of M.tuberculosis than with the avirulent (or) the low virulent strains.
为了更好地理解铁在结核病发病机制中的作用，在体外不同游离铁浓度条件下，对耻垢分枝杆菌以及结核分枝杆菌的强毒株、无毒株和低毒株的铁载体生长及产生情况进行了研究。铁浓度的增加导致所有4种菌株的生长（通过细胞干重和活菌计数对数评估）显著增加。然而，这同时伴随着外螯合铁蛋白和分枝杆菌素产生的显著减少，表明这些铁载体仅在缺铁条件下是必需的。结核分枝杆菌强毒株的铁载体生长及产生情况显著高于无毒株（或）低毒株。
